Encino Hotel is located in the heart of downtown of Puerto Vallarta just one block away from the beach and from the flea market, 1.4 kilometers (0.9 mi) from the Malecon, and the most popular nightclubs, restaurants and bars. The hotel is set right by the Cuale river, 9 kilometers (5.6 mi) south from the international airport of Puerto Vallarta (PVR).

The hotel offers 75 rooms and suites featuring amenities such as air conditioning, cable television, telephone, and wireless internet access. Suites also have a kitchenette and sitting area. Most rooms have a view to the river and some have a small view to the ocean from their private balcony.

Hotel Encino Suites at Plaza del Rio amenities include a swimming pool with panoramic view and two Jacuzzis in the solarium, as well as safety deposit boxes at the front desk, wake up service, and a tour desk. Additionally, there is a café bar on-site where you can enjoy your favorite cocktail or café at evenings and nights.